YW2036
YW2036 (compound 2a) is a potent Wnt/β-Catenin signaling pathway inhibitor with an IC50 value of 637 nM. YW2036 can be used in research of colorectal cancer (CRC) [1].
Product Specifications
CAS Number
[2131223-92-0]
UNSPSC
12352005
Target
Wnt; β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yw2036.html
Purity
99.48
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C)N(C2=CC=CC=C2)N=C1)NC3=CC=C4C=CC=CC4=N3
Molecular Formula
C20H16N4O
Molecular Weight
328.37
References & Citations
[1]Yang W, et, al. Pyrazole-4-Carboxamide (YW2065) : A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation. J Med Chem. 2019 Dec 26;62 (24) :11151-11164.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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