Tuvusertib

Tuvusertib (M1774; ATR inhibitor 1) is a selective and orally active ATR inhibitor extracted from patent WO2015187451A1, compound I-l, with a Ki value below 1 μΜ[1].

Product Specifications

CAS Number

[1613200-51-3]

Product Name Alternative

M1774; ATR inhibitor 1

UNSPSC

12352005

Target

ATM/ATR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tuvusertib.html

Purity

99.77

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

O=C(NC1=C(C(F)=CN=C1)C2=CN=CN2C)C3=C4N=CC(F)=CN4N=C3N

Molecular Formula

C16H12F2N8O

Molecular Weight

370.32

References & Citations

[1]Nadia AHMAD, et al. Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof. WO2015187451A1|[2]Lin Li, et al. Non-canonical role for the ataxia-telangiectasia-Rad3 pathway in STAT3 activation in human multiple myeloma cells