HS-243
HS-243 is a potent and selective IRAK-4 and IRAK-1 inhibitor, with IC50 values of 20 and 24 nM. HS-243 shows minimal TAK1 (transforming growth factor β-activated kinase 1) inhibition activity, with a IC50 of 0.5 μM. HS-243 shows anti-inflammatory and anticancer activity[1].
Product Specifications
CAS Number
[848249-10-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
CDK; IRAK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hs-243.html
Purity
99.95
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC2=CC=CC=C2N1CCC)C3=CC=CC([N+]([O-])=O)=C3
Molecular Formula
C17H16N4O3
Molecular Weight
324.33
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CLK; IRAK1; IRAK4
Available Sizes
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