8-Bromoadenine

8-Bromoadenine (8-Bromo-9H-purin-6-amine) is a DNA radiosensitizer that inhibits DNA single-strand break repair in cells. 8-Bromoadenine is a brominated derivative of adenine, and radioactive adenine can be prepared by replacing bromine with deuterium[1][2].

Product Specifications

CAS Number

[6974-78-3]

Product Name Alternative

8-Bromo-9H-purin-6-amine

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents; DNA/RNA Synthesis

Type

Biochemical Assay Reagents

Related Pathways

Cell Cycle/DNA Damage; Others

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/8-bromoadenine.html

Purity

98.92

Solubility

0.1 M NaOH : 0.2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

BrC1=NC2=C(N1)C(N)=NC=N2

Molecular Formula

C5H4BrN5

Molecular Weight

214.03

Precautions

H302, H315, H319, H335

References & Citations

[1]Tkalich A V, et al. Effect of 8-bromoadenine on DNA repair[J]. Tsitologiia, 1980, 22 (8) : 994-997.|[2]Radioactively marked nucleic acid units. German Democratic Republic, DD106383 A1 1974-06-12.