Fluoflavine
Fluoflavine (ML-090) is a selective NOX1 inhibitor with an IC50 of 90 nM. Fluoflavine has >100 selectivity for NOX1 over NOX2, NOX3, NOX4 (all IC50>10 μM) . ML-090 has an IC50 of 360 nM in HEK293 cells[1].
Product Specifications
CAS Number
[531-46-4]
Product Name Alternative
ML-090
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
NADPH Oxidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/fluoflavine.html
Purity
99.41
Solubility
10 mM in DMSO
Smiles
C1(N2)=NC3=C(C=CC=C3)NC1=NC4=C2C=CC=C4
Molecular Formula
C14H10N4
Molecular Weight
234.26
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]SJ Brown, et al. Probe Report for NOX1 Inhibitors.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NOX1
Available Sizes
Curated Selection
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