Miclxin
Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex[1].
Product Specifications
CAS Number
[2494198-61-5]
Product Name Alternative
DS37262926
UNSPSC
12352005
Target
Apoptosis; Wnt; β-catenin
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/miclxin.html
Concentration
10mM
Purity
98.12
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
COC1=CC(CNC2=C3C=CC(OC)=CC3=NC(N4CC(C5=CC=CN=C5)CC4)=N2)=CC=C1
Molecular Formula
C26H27N5O2
Molecular Weight
441.52
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-138301/Miclxin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-138301/Miclxin-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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