Axinelline A

Axinelline A is a potent COX inhibitor with IC50s of 2.22 μM and 8.89 μM against COX-2 and COX-1, respectively. Axinelline A shows anti-inflammatory activity[1].

Product Specifications

CAS Number

[1593741-99-1]

UNSPSC

12352005

Target

COX

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/axinelline-a.html

Solubility

10 mM in DMSO

Smiles

CCOC([C@H](CO)NC(C1=C(C(O)=CC=C1)O)=O)=O

Molecular Formula

C12H15NO6

Molecular Weight

269.25

References & Citations

[1]Ju Z, et al. Synthesis and Anti-Inflammatory Activity of the Natural Cyclooxygenase-2 Inhibitor Axinelline A and Its Analogues. J Nat Prod. 2023 Apr 28;86 (4) :958-965.