NSC 185058
NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. Inhibition of ATG4B using NSC 185058 markedly attenuates autophagic activity[1].
Product Specifications
CAS Number
[39122-38-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Atg4; Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NSC_185058.html
Purity
99.46
Solubility
DMSO : ≥ 125 mg/mL
Smiles
S=C(C1=NC=CC=C1)NC2=NC=CC=C2
Molecular Formula
C11H9N3S
Molecular Weight
215.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Huang T, et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell. 2017 Dec 11;32 (6) :840-855.e8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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