NSC 185058

NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. Inhibition of ATG4B using NSC 185058 markedly attenuates autophagic activity[1].

Product Specifications

CAS Number

[39122-38-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Atg4; Autophagy

Type

Reference compound

Related Pathways

Autophagy

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NSC_185058.html

Purity

99.46

Solubility

DMSO : ≥ 125 mg/mL

Smiles

S=C(C1=NC=CC=C1)NC2=NC=CC=C2

Molecular Formula

C11H9N3S

Molecular Weight

215.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Huang T, et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell. 2017 Dec 11;32 (6) :840-855.e8.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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