5-Methoxytryptamine

5-Methoxytryptamine, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine is also a potent antioxidant and has radioprotective action[1][2][3].

Product Specifications

CAS Number

[608-07-1]

Product Name Alternative

O-Methylserotonin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor; Drug Metabolite; Endogenous Metabolite

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-5-methoxy-1h-indol-3-yl-ethanamine.html

Purity

99.91

Solubility

DMSO : 200 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)

Smiles

COC1=CC2=C(NC=C2CCN)C=C1

Molecular Formula

C11H14N2O

Molecular Weight

190.25

Precautions

H302, H315, H319, H335

References & Citations

[1]J Yamada, et al. Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor. Eur J Pharmacol. 1997 Apr 4;323 (2-3) :235-40. |[2]S Bayari, et al. Fourier transform infrared spectra and molecular structure of 5-methoxytryptamine, N-acetyl-5-methoxytryptamine and N-phenylsulfonamide-5-methoxytryptamine. Spectrochim Acta A Mol Biomol Spectrosc. 2003 Apr;59 (6) :1255-63.|[3]D A Craig, et al. 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum. Naunyn Schmiedebergs Arch Pharmacol. 1990 Jul;342 (1) :9-16.