COX-2-IN-44

COX-2-IN-44 is a potent and orally active COX-2 inhibitor with IC50 values of 0.18,1.14 µM for COX-2, COX-1, respectively. COX-2-IN-44 shows anti-inflammatory activity[1].

Product Specifications

UNSPSC

12352005

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cox-2-in-44.html

Smiles

CC(C=C1)=CC=C1NC(C(CC2=CC=C(Cl)C=C2)=C3)=NN=C3/C=C/C4=CC=C(OC)C=C4

Molecular Formula

C27H24ClN3O

Molecular Weight

441.95

References & Citations

[1]Ewieda SY, et al. Synthesis, COX-2 inhibition, anti-inflammatory activity, molecular docking, and histopathological studies of new pyridazine derivatives. Bioorg Chem. 2024 Sep;150:107623.