NucPE1

NucPE1 (Nuc-H2O2 Probe) is a nuclear-localized fluorescent hydrogen peroxide that is specifically localized to cellular nuclei without appended targeting moieties.

Product Specifications

CAS Number

[1404091-23-1]

Product Name Alternative

Nuc-H2O2 Probe

UNSPSC

12171500

Target

Reactive Oxygen Species (ROS)

Type

Dye Reagents

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/NucPE1.html

Purity

98.0

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1OC2(C3=C(OC4=C2C=CC(B5OC(C)(C)C(C)(C)O5)=C4)C=C(NCC)C(C)=C3)C6=C1C=CC=C6

Molecular Formula

C29H30BNO5

Molecular Weight

483.36

References & Citations

[1]Stanicka J, et al. NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells. J Biol Chem. 2015 Apr 10;290 (15) :9348-61.|[2]Dickinson BC, et al. A nuclear-localized fluorescent hydrogen peroxide probe for monitoring sirtuin-mediated oxidative stress responses in vivo. Chem Biol. 2011 Aug 26;18 (8) :943-8.