KU-60019

KU-60019 is an improved ATM kinase-specific inhibitor with IC50 of 6.3 nM.

Product Specifications

CAS Number

[925701-46-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ATM/ATR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/KU-60019.html

Purity

99.43

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 10 mg/mL (ultrasonic)

Smiles

C[C@@H]1O[C@@H](CN(CC(NC2=CC3=C(C=C2)SC4=C(C3)C=CC=C4C5=CC(C=C(O5)N6CCOCC6)=O)=O)C1)C

Molecular Formula

C30H33N3O5S

Molecular Weight

547.67

Precautions

H302, H315, H319, H335

References & Citations

[1]Golding SE, et al. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther. 2009 Oct;8 (10) :2894-902.|[2]McCabe N, et al. Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM. Cancer Res. 2015 Jun 1;75 (11) :2159-65.