Thalidomide-5-methyl
Thalidomide-5-methyl is the Thalidomide (HY-14658) -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Thalidomide-5-methyl can be used to synthesize PROTAC[1].
Product Specifications
CAS Number
[40313-92-6]
UNSPSC
12352005
Hazard Statement
H301, H312, H361
Target
Apoptosis; Autophagy; Ligands for E3 Ligase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-5-methyl.html
Purity
99.87
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NC(C(CC1)N2C(C3=CC=C(C)C=C3C2=O)=O)=O
Molecular Formula
C14H12N2O4
Molecular Weight
272.26
Precautions
H301, H312, H361
References & Citations
[1]George W. Muller, et al. Substituted 2- (2,6 dioxo-3-fluoropiperidin-3-yl) -isoindolines and method of reducing TNFα levels. Patent US5874448A.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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