PDLI2 rabbit pAb

This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011],

Product Specifications

Background

Product Name Alternative

PDZ and LIM domain protein 2 (PDZ-LIM protein mystique)

UniProt

Q96JY6

Swiss Prot

Q96JY6

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human PDLI2 AA range: 190-240

Target

PDLI2

Clonality

Polyclonal

Source

Rabbit

Applications

Concentration

1 mg/ml

Dilution

WB 1:500-2000

Buffer

-20°C/1 year

Molecular Weight

38kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

38kD

Fragment

IgG

Subcellular Location

Cytoplasm . Nucleus . May be partially nuclear.; [Isoform 1]: Cytoplasm, cytoskeleton. Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN) .; [Isoform 2]: Cytoplasm, cytoskeleton.; [Isoform 3]: Nucleus.