Docebenone

Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.

Product Specifications

CAS Number

[80809-81-0]

Product Name Alternative

AA 861

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Ferroptosis; Lipoxygenase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Docebenone.html

Concentration

10mM

Purity

99.02

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1C(CCCCC#CCCCC#CCO)=C(C)C(C(C)=C1C)=O

Molecular Formula

C21H26O3

Molecular Weight

326.43

Precautions

H315, H319, H335

References & Citations

[1]Nam YH, et al. Leukotriene B (4) receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products. Inflamm Res. 2012 Feb;61 (2) :97-102.|[2]Huang JK, et al. AA-861-induced Ca (2+) mobilization in Madin Darby canine kidney cells. Toxicol Appl Pharmacol. 1999 Dec 1;161 (2) :202-8.|[3]Kiriyama M, et al. Protective effect of AA-861 (5-lipoxygenase inhibitor) on experimental acute necrotizing pancreatitis in rats. Int J Pancreatol. 1993 Jun;13 (3) :201-8.|[4]Yamamura H, et al. Effect of AA-861, a selective 5-lipoxygenase inhibitor, on models of allergy in several species. Jpn J Pharmacol. 1988 Jul;47 (3) :261-71.