JAK2-IN-11
Product Specifications
UNSPSC Description
JAK2-IN-11 (Example 6) is a JAK2 kinase inhibitor with IC50 ≤10 nM against JH2 BIND WT/V617F. JAK2-IN-11 has antitumor activity[1].
Target Antigen
JAK
Type
Isotope-Labeled Compounds
Related Pathways
Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C1N([C@H]2C[C@@H](CC2)NC(OC)=O)C3=CC(NC4=NC5=C(C=CC=C5C(F)(F)F)C(C(N6CCC(CC6)C#N)=O)=C4)=NC=C3N1C([2H])([2H])[2H]
Molecular Weight
639.64
References & Citations
[1]Xin Li, et al. Bicyclic ureas as kinase inhibitors. WO2024191996A1.2024-09-19.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
3057053-17-2
Curated Selection
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