Nocodazole

Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.

Product Specifications

CAS Number

[31430-18-9]

Product Name Alternative

Oncodazole; R17934

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Bcr-Abl; CRISPR/Cas9; Microtubule/Tubulin; Mitosis

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Nocodazole.html

Purity

99.59

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(OC)NC1=NC2=CC=C(C(C3=CC=CS3)=O)C=C2N1

Molecular Formula

C14H11N3O3S

Molecular Weight

301.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Park H, et al. Nocodazole is a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK. ChemMedChem. 2012 Jan 2;7 (1) :53-6.|[2]Keliang Xu, et al. Interaction of nocodazole with tubulin isotypes. Drug Development Research 2002|[3]Wang YJ, et al. R-41400 potentiates the antitumor effects of nocodazole: In vivo therapy for human tumor xenografts in nude mice. Mol Carcinog. 2002 Aug;34 (4) :199-210.|[4]Signoretto E, et al. Nocodazole Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem. 2016;38 (1) :379-92.|[5]Zhang JP, et al. Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage. Genome Biol. 2017 Feb 20;18 (1) :35.|[6]Anutosh Ganguly, et al. The role of microtubules and their dynamics in cell migration. J Biol Chem. 2012 Dec 21;287 (52) :43359-69.