K6PC-5

K6PC-5, a ceramide derivative, is a sphingosine kinase 1 (SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the potential for skin diseases involving abnormal keratinocyte, and neurodegeneration and virus infection research[1][2][3].

Product Specifications

CAS Number

[756875-51-1]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Filovirus; SphK

Type

Reference compound

Related Pathways

Anti-infection; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/k6pc-5.html

Purity

99.27

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCCCC(C(C(NC(CO)CO)=O)CCCCCC)=O

Molecular Formula

C19H37NO4

Molecular Weight

343.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Kwon YB, et al. Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation. J Lipid Res. 2007 Sep;48 (9) :1936-43. |[2]Jong-Kyung Youm, et al. K6PC-5, a sphingosine kinase activator, induces anti-aging effects in intrinsically aged skin through intracellular Ca2+ signaling. J Dermatol Sci. 2008 Aug;51 (2) :89-102.|[3]Imre G, et al. The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection. iScience. 2021 Mar 5;24 (4) :102266.