EMD386088

EMD386088 is a potent and selective 5-HT6 receptor (5-HT6R) agonist with an EC50 of 1.0 nM. EMD-386088 is inactive against other HT receptors except 5-HT3R (IC50 of 34 nM) . EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential for the research of alzheimer's disease (AD) and schizophrenia[1][2][3][4].

Product Specifications

CAS Number

[1171123-46-8]

UNSPSC

12352005

Hazard Statement

H301

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/emd386088.html

Purity

99.06

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(N1)=C(C2=CCNCC2)C3=C1C=CC(Cl)=C3.[H]Cl

Molecular Formula

C14H16Cl2N2

Molecular Weight

283.20

Precautions

H301

References & Citations

[1]Yun HM, et al. 5-HT6 receptor ligands, EMD386088 and SB258585, differentially regulate 5-HT6 receptor-independent events. Toxicol In Vitro. 2011 Dec;25 (8) :2035-40.|[2]Meneses A, et al. The effects of the 5-HT (6) receptor agonist EMD and the 5-HT (7) receptor agonist AS19 on memory formation. Behav Brain Res. 2008 Dec 16;195 (1) :112-9. |[3]Amodeo DA, et al. 5-HT6 receptor agonist EMD386088 impairs behavioral flexibility and working memory. Behav Brain Res. 2018 Sep 3;349:8-15.|[4]Mattsson C, et al. 2-Alkyl-3- (1,2,3,6-tetrahydropyridin-4-yl) -1H-indoles as novel 5-HT6 receptor agonists. Bioorg Med Chem Lett. 2005 Oct 1;15 (19) :4230-4.