Fluorofolin
Product Specifications
UNSPSC Description
Fluorofolin is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.5 nM. Fluorofolin exhibits significant activity against P. aeruginosa[1].
Target Antigen
Bacterial; Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/fluorofolin.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(N)=NC2=C1C(C=CN3CC4=CC=NC(F)=C4)=C3C=C2
Molecular Weight
308.31
References & Citations
[1]Connor Chain, et al. A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting. Nat Microbiol. 2024 May;9(5):1207-1219.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162475/Fluorofolin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162475/
Clinical Information
No Development Reported
CAS Number
2757070-32-7
Curated Selection
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