SW-100

SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier[1].

Product Specifications

CAS Number

[2126744-35-0]

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sw-100.html

Purity

99.93

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=C(NO)C1=CC=C(CN2CCCC3=C2C=CC(Cl)=C3)C=C1

Molecular Formula

C17H17ClN2O2

Molecular Weight

316.78

References & Citations

[1]Kozikowski AP, et al. Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and LearningImpairments in a Mouse Model of Fragile X Syndrome. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1679-1695.