Anticancer agent 253
Product Specifications
UNSPSC Description
Anticancer agent 253 (Compound 26) has anti-cancer activity against breast cancer cells, with IC50s of 6 μM (MCF-7), 10 μM (MDA-MB-231) and 6.4 μM (4T1 cells). Anticancer agent 253 arrests cell cycle and induces mitochondria-mediated apoptosis in cancer cells. Anticancer agent 253 inhibits Akt phosphorylation in human breast and prostate cancer[1].
Target Antigen
Akt; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis;PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-253.html
Smiles
O=C(/C(CN(C/1)CC2=CN(N=N2)CC3=CC=C(C=C3)F)=C/C4=C(C=CC=C4)F)C1=C\C5=C(C=CC=C5)F
Molecular Weight
500.51
References & Citations
[1]Mandalapu D, et al. Synthesis and biological evaluation of some novel triazole hybrids of curcumin mimics and their selective anticancer activity against breast and prostate cancer cell lines. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4223-32.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-116904/Anticancer-agent-253-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-116904/
Clinical Information
No Development Reported
CAS Number
9007-83-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
