BTK degrader-1
Product Specifications
UNSPSC Description
BTK degrader-1 (compound 1) is a Bruton’s tyrosine kinase (BTK) bifunctional degrader that can be conjugated with CD79b. BTK degrader-1 (compound 1) has anti-tumor effect[1].
Target Antigen
ADC Cytotoxin; Btk
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/btk-degrader-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C(C)(C)O)C=C1F)NC2=CC(F)=CC(C3=C4C=C(C5=CC=C(CCN6CCC7(CC6)CCN(CC7)C(C8=CC=C(C(N9C(NC(CC9)=O)=O)=C8)OC)=O)C=C5)NC4=NC=N3)=C2C
Molecular Weight
925.03
References & Citations
[1]Alan Zhang, et al. Design, Synthesis, and In Vitro and In Vivo Evaluation of Cereblon Binding Bruton’s Tyrosine Kinase (BTK) Degrader CD79bTargeted Antibody–Drug Conjugates. Bioconjug Chem. 2024 Feb 21;35(2):140-146.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163295/BTK-degrader-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163295/
Clinical Information
No Development Reported
CAS Number
2377645-56-0
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