Naphthazarin

Naphthazarin (DHNQ) is a microtubule depolymerizing agent. Naphthazarin can improve motor function and reduce neuroinflammation in mouse models of Parkinson's disease. Naphthazarin can induce tumor cell apoptosis, autophagy, and cell cycle arrest. Naphthazarin can also induce erythrocyte apoptosis. Naphthazarin can be used in the research of tumors and neurodegenerative diseases[1][2][3].

Product Specifications

CAS Number

[475-38-7]

Product Name Alternative

DHNQ; 5,8-Dihydroxy-1,4-naphthoquinone

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H315, H319

Target

Akt; Apoptosis; Autophagy; PI3K

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/naphthazarin.html

Purity

99.59

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

O=C1C=CC(C2=C1C(O)=CC=C2O)=O

Molecular Formula

C10H6O4

Molecular Weight

190.15

Precautions

H302+H312+H332, H315, H319

References & Citations

[1]Seon Young Choi, et al. Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model. J Neurosci Res. 2012 Sep;90 (9) :1842-9.|[2]Omar Aljanadi, et al. Stimulation of Suicidal Erythrocyte Death by Naphthazarin. Basic Clin Pharmacol Toxicol. 2015 Dec;117 (6) :369-74.|[3]Acharya BR, et al. The microtubule depolymerizing agent naphthazarin induces both apoptosis and autophagy in A549 lung cancer cells. Apoptosis. 2011 Sep;16 (9) :924-39. doi: 10.1007/s10495-011-0613-1