COMT-IN-1
Product Specifications
UNSPSC Description
COMT-IN-1 (compound C12), a nitrophenolic analogue, is an orally active dopamine metabolic enzyme catechol-O-methyltransferase (COMT) inhibitor with IC50s of 0.37 μM, 95.58 μM and 58.82 μM for COMT, MAO-A and MAO-B, respectively. COMT-IN-1 exhibits chelation with a variety of metal ions. COMT-IN-1 exhibits good BBB permeability. COMT-IN-1 improves dopamine levels and ameliorates MPTP (HY-15608)-induced Parkinson's disease (PD) symptoms in mice[1].
Target Antigen
COMT; Monoamine Oxidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/comt-in-1.html
Smiles
OC1=C([N+]([O-])=O)C=C(/C=C(C(NCC2=CC=C(OCC3=CC=CC(F)=C3)C=C2)=O)\C#N)C=C1O
Molecular Weight
463.41
References & Citations
[1]Manxing Zou, et al. Identification and optimization of nitrophenolic analogues as dopamine metabolic enzyme inhibitors for the treatment of Parkinson's disease. Bioorg Chem. 2024 Jul:148:107488.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162760/COMT-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162760/
Clinical Information
No Development Reported
CAS Number
2987884-27-3
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