Ionomycin

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[1]Liu C, et al. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253 (17) :5892-4.|[2]Chatila T, et al. Mechanisms of T cell activation by the calcium ionophore ionomycin. J Immunol. 1989 Aug 15;143 (4) :1283-9.|[3]Gil-Parrado S, et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277 (30) :27217-26.|[4]Stoeck A, et al A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. Biochem J. 2006 Feb 1;393 (Pt 3) :609-18.|[5]Junsuke Uwada, et al. Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells. Cell Signal. 2019 Nov;63:109358.

ACS Infect Dis. 2023 Apr 14;9 (4) :979-992.|Acta Pharm Sin B. 2024 Oct;14 (10) :4360-4377.|Acta Pharmacol Sin. 2023 Apr;44 (4) :811-821.|Adv Funct Mater. 2025 May 22.|Adv Sci (Weinh) . 2023 Mar;10 (7) :e2203869.|Adv Sci (Weinh) . 2024 Jul;11 (26) :e2400297.|Adv Sci (Weinh) . 2024 May;11 (19) :e2306378.|Adv Sci (Weinh) . 2025 Jun 19:e00225.|Adv Sci (Weinh) . 2025 Sep 15:e10102.|Aging (Albany NY) . 2021 Mar 24;13 (7) :10312-10325.|Aging. 2019 Aug 19;11 (16) :6490-6502.|Aging. 2021 Jun 2;13 (11) :15638-15658.|Arch Oral Biol. 2024 Jul 3:166:106043.|Biochem Pharmacol. 2024 Jan:219:115957.|Biochem Pharmacol. 2025 Dec;242 (Pt 3) :117406.|Biomed Pharmacother. 2022 Mar:147:112644.|Biomed Pharmacother. 2024 May:174:116551.|BMC Med. 2023 Dec 20;21 (1) :507.|BMC Med. 2025 Mar 31;23 (1) :189.|Cancer Cell. 2023 Jun 12;41 (6) :1170-1185.e12.|Cancer Commun (Lond) . 2022 Jan;42 (1) :17-36.|Cancer Immunol Res. 2025 Jul 2;13 (7) :1037-1052.|Cancer Res. 2023 Mar 15;83 (6) :906-921.|Cell Calcium. 2022 Jun;104:102571.|Cell Death Differ. 2025 Apr 16.|Cell Death Dis. 2021 Apr 1;12 (4) :336.|Cell Death Dis. 2025 Apr 15;16 (1) :301.|Cell Metab. 2024 Jun 18:S1550-4131 (24) 00189-X.|Cell Mol Immunol. 2022 Apr;19 (4) :540-553.|Cell Mol Life Sci. 2025 May 28;82 (1) :218.|Cell Rep. 2021 Jul 20;36 (3) :109404.|Cell Rep. 2024 Mar 23;43 (4) :114003.|Cell Rep. 2025 Jun 12;44 (6) :115857.|Cell Rep. 2025 Jun 13;44 (6) :115851.|Cell Rep. 2025 Sep 1;44 (9) :116139.|Cell Res. 2025 Feb;35 (2) :97-116.|Cell Stem Cell. 2025 May 1;32 (5) :778-794.e10.|Cell. 2025 Dec 11;188 (25) :7291-7308.e23.|Cytotechnology. 2024 Apr 24:1-8.|EBioMedicine. 2024 Aug 6:106:105269.|Ecotoxicol Environ Saf. 2024 Jan 15:270:115831.|EMBO Rep. 2025 Nov 17.|Eur J Med Res. 2025 May 12;30 (1) :378.|Eur J Pharmacol. 2022 Feb 5:916:174623.|Evid Based Complement Alternat Med. 2021 Jan 6:2021:8868527.|Fish Shellfish Immunol. 2024 May:148:109515.|Fish Shellfish Immunol. 2024 Nov:154:109975.|Front Immunol. 2022 Aug 5:13:918241.|Gut Microbes. 2024 Jan-Dec;16 (1) :2410474.|Hum Reprod. 2024 Apr 3;39 (4) :658-673.|Int Immunopharmacol. 2023 Sep 1;124 (Pt A) :110865.|Int Immunopharmacol. 2024 Sep 16;142 (Pt B) :113170.|Int Immunopharmacol. 2025 May 20:159:114897.|Int Immunopharmacol. 2026 Jan 1;168 (Pt 1) :115803.|Int J Biol Macromol. 2023 Jul 31:244:125373.|Int J Mol Sci. 2023 Aug 8;24 (16) :12557.|Int J Mol Sci. 2025 Jun 1;26 (11) :5332.|Int J Mol Sci. 2025 May 20;26 (10) :4913.|iScience. 2025 May 13;28 (7) :112658.|J Cell Mol Med. 2024 Aug;28 (15) :e18589.|J Cell Mol Med. 2025 Feb;29 (3) :e70403.|J Cell Mol Med. 2025 Oct;29 (20) :e70915.|J Clin Invest. 2025 Aug 1;135 (15) :e191119.|J Ethnopharmacol. 2023 Mar 1:303:116031.|J Immunol. 2021 Mar 1;206 (5) :963-977.|J Immunother Cancer. 2024 Dec 9;12 (12) :e009910.|J Immunother Cancer. 2025 Jul 31;13 (7) :e012029.|J Nanobiotechnology. 2024 Sep 12;22 (1) :556.|J Neuroimmunol. 2020 Aug 15;345:577286.|J Periodontol. 2025 Apr;96 (4) :355-368.|J Transl Med. 2024 Dec 20;22 (1) :1125.|J Transl Med. 2025 Nov 14;23 (1) :1289.|Microorganisms. 2023 Feb 27;11 (3) :604.|Mol Cell. 2022 Jul 7;82 (13) :2401-2414.e9.|Mol Med. 2024 Jul 30;30 (1) :110.|Nat Cancer. 2025 May;6 (5) :768-785.|Nat Commun. 2023 Feb 23;14 (1) :1020.|Nat Commun. 2025 Mar 19;16 (1) :2728.|Nat Commun. 2025 Nov 24;16 (1) :10384.|Oncol Rep. 2024 Feb;51 (2) :29.|Phytomedicine. 2025 Jun 20:145:157017.|PLoS Pathog. 2025 Feb 4;21 (2) :e1012912.|PLoS Pathog. 2025 Nov 14;21 (11) :e1013686.|Preprints. 2023 Mar 6.|Preprints. 2025 Feb 12.|Proc Natl Acad Sci U S A. 2022 Feb 22;119 (8) :e2114851119.|Protein Cell. 2022 Apr;13 (4) :281-301.|Redox Biol. 2023 Dec:68:102959.|Reprod Fert Develop. 33 (2) 108-108.|Research Square Preprint. 2023 Aug 11.|Research Square Print. 2022 Jun.|Sci Signal. 2023 Feb 28;16 (774) :eadd0645.|Sci Total Environ. 2021 Jul 20:779:146523.|Sci Transl Med. 2020 Nov 25;12 (571) :eaaz6667.|SSRN. 2025 Jul 24.|Theranostics. 2023 May 8;13 (9) :2879-2895.|Theranostics. 2025 May 25;15 (13) :6329-6346.|Vaccines. 2023 May 25;11 (6) :1026.|Vet Microbiol. 2025 Apr 23:305:110529.|Virulence. 2025 Oct 28:2580150.|Cell Host Microbe. 2025 Jun 11;33 (6) :915-931.e9.|Immunobiology. 2024 Nov;229 (6) :152854.|Int Immunopharmacol. 2024 Jan 5:126:111212.|J Cell Sci. 2025 Nov 17:jcs.264186.|OncoImmunology. 2023 Oct 12;12 (1) :2268257.