Dopal

Dopal is an aldehyde that can be generated in Parkinson's disease by enzymatic degradation of dopamine. Dopal can generate reactive oxygen species (ROS), and triggers aggregation of α-synuclein. Dopal elicits α-synuclein accumulation and hampers α-synuclein clearance in primary neurons[1][2].

Product Specifications

CAS Number

[5707-55-1]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

α-synuclein

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dopal.html

Concentration

65.72 mM * 500 μL in Methanol

Purity

90.0

Smiles

O=CCC1=CC=C(O)C(O)=C1

Molecular Formula

C8H8O3

Molecular Weight

152.15

Precautions

H302, H312, H332

References & Citations

[1]Masato A, et al. DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson's disease. NPJ Parkinsons Dis. 2023 Mar 25;9 (1) :42. |[2]Bloch DN, et al. Scavenging neurotoxic aldehydes using lysine carbon dots. Nanoscale Adv. 2023 Jan 19;5 (5) :1356-1367.