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Anti-SOX9 / SRY-box 9 (SOX9/2387), CF488A conjugate

Sox genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. SOX9 plays an important role in the normal skeletal development. It may regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Specifications

Synonyms

Campomelic Dysplasia Autosomal Sex Reversal (CMD1); SRA1; SRXX2; SRY (sex determining region Y) box 9; SRY related HMG box gene 9; Transcription factor SOX9

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

SOX9

Gene ID

6662

NCBI Gene ID

647409

UniProt

P48436

Cellular Locus

Nucleus

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant human SOX9 protein fragment (around aa 393-508) (exact sequence is proprietary)

Target Antigen

SOX9 | SRY-box 9

Clonality

Monoclonal

Isotype

IgG1 κ

Clone

SOX9/2387

Conjugation

CF488A

Source

Animal

Field of Research

Cancer, Developmental biology, Transcription factors

Positive Control

HepG2 Cells. Pancreas

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

65 kDa

Additionnal Information

For coating for ELISA, order Ab without BSA|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Optimal dilution and staining procedure for a specific application should be determined by user|Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry

References & Citations

Zhu, H., et al. 2013. Upregulation of SOX9 in osteosarcoma and its association with tumor progression and patients prognosis. Diagn.Pathol. 8:183.|

Shipping Conditions

Room temperature

Storage Conditions

4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

2 years

Product Datasheet

https://cdn.gentaur.com/products/37/910048/datasheet/bnc882387-500.pdf

Product MSDS

https://cdn.gentaur.com/products/37/910048/msds/bnc882387-500.pdf

CAS Number

9007-83-4

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