Neuropeptide AF (cattle)

Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR) ) (EC50 of ~60 nM) and MrgprC11 (EC50 of ~300 nM) . Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC50 of ~25-325 nM) and NPFF2 (EC50 of ~1-5 nM) . Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects[1][2].

Product Specifications

CAS Number

[99588-52-0]

UNSPSC

12352209

Target

Mas-related G-protein-coupled Receptor (MRGPR) ; Neuropeptide Y Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/neuropeptide-af-cattle.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1N(CCC1)C([C@H](CO)NC([C@H](CO)NC([C@H](CC(C)C)NC(CNC([C@H](CCC(O)=O)NC(CNC([C@@H](N)C)=O)=O)=O)=O)=O)=O)=O)N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](C)C(N3[C@@H](CCC3)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O

Molecular Formula

C89H130N24O24

Molecular Weight

1920.13

References & Citations

[1]Nada Abdellah, et al. Neuropeptide AF Induces Piecemeal Degranulation in Murine Mucosal Mast Cells: A New Mediator in Neuro-Immune Communication in the Intestinal Lamina Propria? Anat Rec (Hoboken) . 2018 Jun;301 (6) :1103-1114.|[2]Miklós Palotai, et al. Neuropeptide AF induces anxiety-like and antidepressant-like behavior in mice. Behav Brain Res. 2014 Nov 1;274:264-9.