SMD-3040 intermediate-2

SMD-3040 intermediate-2 is an intermediate in the synthesis of SMD-3040 (HY-156568) . SMD-3040 contains SMARCA2/4 ligands, linker and VHL ligands and is a selective SMARCA2 degrader. MD-3040 can be used for ADC drug synthesis and has strong tumor growth inhibition in tumor xenograft models[1].

Product Specifications

CAS Number

[2632308-00-8]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

Drug Intermediate

Type

ADC Related

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/smd-3040-intermediate-2.html

Purity

95.82

Solubility

10 mM in DMSO

Smiles

N#CC1=CC=C(N2CC3(CC2C)CCN(CC3)C(OC(C)(C)C)=O)C=C1Cl

Molecular Formula

C21H28ClN3O2

Molecular Weight

389.92

Precautions

H302, H315, H319, H335

References & Citations

[1]Yang L, et.al. Discovery of SMD-3040 as a Potent and Selective SMARCA2 PROTAC Degrader with Strong in vivo Antitumor Activity. J Med Chem. 2023 Jul 31.