Calotatug ginistinag
Product Specifications
UNSPSC Description
Calotatug ginistinag (XMT-2056) is an antibody-drug conjugate targeting HER2, with an effective payload connected via a linker (LP, HY-148067) to a STING agonist (STING agonist-20, HY-148068), and has potential immune activation and anticancer activity[1].
Target Antigen
Antibody-Drug Conjugates (ADCs); EGFR; STING
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related;Immunology/Inflammation;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/calotatug-ginistinag.html
Smiles
[Calotatug ginistinag]
References & Citations
[1]Duvall J R, et al. XMT-2056, a HER2-targeted Immunosynthen STING-agonist antibody-drug conjugate, binds a novel epitope of HER2 and shows increased anti-tumor activity in combination with trastuzumab and pertuzumab[J]. Cancer Res, 2022, 82(12_Supplement): 3503-3503.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164919/Calotatug-ginistinag-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164919/
Clinical Information
No Development Reported
CAS Number
2847102-44-5
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