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Anti-PTEN (Tumor Suppressor Oncoprotein) (PTEN/2110)

PTEN (phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase) contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. It was identified as a tumor suppressor that is mutated in a large number of cancers, including sporadic brain, breast, kidney, and prostate cancers.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Specifications

Synonyms

BZS; DEC; GLM2; MHAM; Mutated in Multiple Advanced Cancers 1 (MMAC1); MMAC1 phosphatase and tensin homolog deleted on chromosome 10; Phosphatase and Tensin Homolog; Phosphatase and tensin like protein; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase; PTEN; PTEN1; TEP1

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

PTEN

Gene ID

5278

NCBI Gene ID

500466; 729457

UniProt

P60484

Cellular Locus

Nucleus & cytoplasm

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant full-length human PTEN protein

Target Antigen

PTEN

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

PTEN/2110

Conjugation

Purified, with BSA

Source

Animal

Applications

IHC, FFPE (verified)

Validated Applications

IHC,FFPE

Field of Research

Signal transduction, Tumor suppressors

Positive Control

MCF-7 or HeLa Cells. Prostate, Breast, Liver, Renal Carcinoma.

Concentration

0.2 mg/mL

Buffer

PBS, 0.05% BSA, 0.05% azide

Molecular Weight

55 kDa

Additionnal Information

Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunohistology (formalin): 1-2 ug/mL for 30 minutes at RT|Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes|Optimal dilution for a specific application should be determined by user

Shipping Conditions

Room temperature

Storage Conditions

4°C; Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

2 years

Product Datasheet

https://cdn.gentaur.com/products/37/906547/datasheet/bnub2110-500.pdf

Product MSDS

https://cdn.gentaur.com/products/37/906547/msds/bnub2110-500.pdf

CAS Number

9007-83-4

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