KU-0058684
Product Specifications
UNSPSC Description
KU-0058684 is a potent PARP inhibitor, with an IC50 of 3.2 nM for PARP-1. KU-0058684 significantly reduces DNA double strand break (DSB) repair[1][2].
Target Antigen
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ku-0058684.html
Smiles
O=C(N1C2=CC(CC3=NNC(C4=C3C=CC=C4)=O)=CC=C2F)CCC1=O
Molecular Weight
351.33
References & Citations
[1]Mitchell J, et al. Poly(ADP-Ribose) polymerase-1 and DNA-dependent protein kinase have equivalent roles in double strand break repair following ionizing radiation. Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1520-7.|[2]McCabe N, et al. BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency. Cancer Biol Ther. 2005 Sep;4(9):934-6.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-123232/KU-0058684-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-123232/
Clinical Information
No Development Reported
CAS Number
623578-11-0
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