ATC0065

ATC0065 is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC50 of 15.7 nM for human MCHR1. ATC0065 does not exhibits significant activity for MCHR2. ATC0065 has anxiolytic and antidepressant activities[1].

Product Specifications

CAS Number

[510732-84-0]

UNSPSC

12352005

Target

5-HT Receptor; MCHR1 (GPR24)

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/atc0065.html

Purity

99.09

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN(C)C1=C2C=CC=CC2=NC(N[C@H]3CC[C@@H](NCCC4=CC=C(Br)C=C4OC(F)(F)F)CC3)=N1.Cl.Cl

Molecular Formula

C25H31BrCl2F3N5O

Molecular Weight

625.35

References & Citations

[1]Shigeyuki Chaki, et al. Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J Pharmacol Exp Ther. 2005 May;313 (2) :831-9.