NAcM-OPT (hydrochloride)

NAcM-OPT (hydrochloride) is a protein interaction inhibitor. NAcM-OPT (hydrochloride) can disrupt the interaction between DCN1 and UBC12, with an IC50 value of 80 nM. NAcM-OPT (hydrochloride) can protect keratinocytes from H2O2-induced cell damage by promoting autophagy[1][2].

Product Specifications

CAS Number

[2416146-10-4]

UNSPSC

12352005

Target

Autophagy

Type

Reference compound

Related Pathways

Autophagy

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/nacm-opt-hydrochloride.html

Smiles

O=C(NC1=CC=C(Cl)C(Cl)=C1)N(C2CCN(CCCC)CC2)CC3=CC=CC=C3.Cl

Molecular Formula

C23H30Cl3N3O

Molecular Weight

470.86

References & Citations

[1]Fang Y, et al. Targeting the DCN1-UBC12 protein-protein interaction: novel approaches and future directions. Future Med Chem. 2019 Nov;11 (22) :2869-2871.|[2]Xiong R, et al. NAcM-OPT protects keratinocytes from H2O2-induced cell damage by promoting autophagy. Ann N Y Acad Sci. 2024 Jul;1537 (1) :155-167.