Riluzole
Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.
Product Specifications
CAS Number
[1744-22-5]
Product Name Alternative
PK 26124
UNSPSC
12352005
Hazard Statement
H300
Target
GABA Receptor; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/riluzole.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Smiles
NC1=NC2=CC=C(OC(F)(F)F)C=C2S1
Molecular Formula
C8H5F3N2OS
Molecular Weight
234.20
Precautions
H300
References & Citations
[1]He Y, et al. Neuroprotective agent riluzole potentiates postsynaptic GABA (A) receptor function. Neuropharmacology. 2002 Feb;42 (2) :199-209.|[2]Thompson JM, et al. Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain. Mol Pain. 2015 Aug 28;11:51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Cell Res. 2022 Jun;32 (6) :555-569.|EMBO Mol Med. 2025 Oct 15.|Free Radic Biol Med. 2024 May 1:217:126-140.|Front Cell Neurosci. 2020 Oct 16;14:575626.|Front Neural Circuits. 2021 Apr 6:15:657445.|J Neurochem. 2025 Oct;169 (10) :e70246.|Nat Commun. 2023 Dec 12;14 (1) :8255.|Nat Neurosci. 2025 Nov 24.|Neurosci Lett. 2021 May 14:753:135846.|Pharmacol Biochem Behav. 2018 May:168:43-50.|Proc Natl Acad Sci U S A. 2023 Oct 10;120 (41) :e2309773120.|Res Sq. 2024 Jul 09.|Adv Sci (Weinh) . 2025 Oct 20:e07908.
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