1-Alaninechlamydocin
Product Specifications
UNSPSC Description
1-Alaninechlamydocin, a cyclic tetrapeptide, is a potent HDAC inhibitor (IC50=6.4 nM). 1-Alaninechlamydocin induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells[1].
Target Antigen
Apoptosis; HDAC
Type
Peptides
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1-alaninechlamydocin.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NC([C@@H]1C)=O)CC2=CC=CC=C2)N(CCC3)[C@@]3([H])C(N[C@H](C(N1)=O)CCCCCC([C@@H]4CO4)=O)=O
Molecular Weight
512.60
References & Citations
[1]Du L, et al. A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells. J Nat Prod. 2014;77(7):1753-1757.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P2698/1-Alaninechlamydocin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P2698/
Clinical Information
No Development Reported
CAS Number
141446-96-0
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