5J-4

5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation[1].

Product Specifications

CAS Number

[827001-82-1]

UNSPSC

12352005

Target

CRAC Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/5j-4.html

Purity

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CO1)NC(NC2=CC=CC3=C2C=CC(O)=C3)=S

Molecular Formula

C16H12N2O3S

Molecular Weight

312.35

References & Citations

[1]Kim KD, et al. Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J Immunol. 2014 Jan 1;192 (1) :110-22.