(RXR) 4XB

(RXR) 4XB is a cell-penetrating peptide, that binds the phosphorodiamidate morpholino oligomers (PMOs), forms peptide-conjugated PMOs (PPMOs), and improves the delivery of PMO into bacterial cells. (RXR) 4XB-PMO conjugate prevents the formation of biofilms, inhibits Pseudomonas aeruginosa with MIC50 of 0.5 to 16 μM, and reduces the bacterial burden in mouse acute pneumonia models[1].

Product Specifications

CAS Number

[879010-15-8]

UNSPSC

12352209

Target

Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/rxr-4xb.html

Smiles

N=C(N)NCCC[C@H](N)C(NCCCCCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCCCCCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCCCCCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCCCCCC(N[C@@H](CCCNC(N)=N)C(NCCCCCC(NCCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C81H158N38O15

Molecular Weight

1904.37

References & Citations

[1]Howard JJ, et al., Inhibition of Pseudomonas aeruginosa by Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers. Antimicrob Agents Chemother. 2017 Mar 24;61 (4) :e01938-16.