GSK1838705A
Product Specifications
UNSPSC Description
GSK1838705A is a potent and reversible IGF-IR and the insulin receptor inhibitor with IC50s of 2.0 and 1.6 nM, respectively. It also inhibits ALK with an IC50 of 0.5 nM.
Target Antigen
Anaplastic lymphoma kinase (ALK); IGF-1R; Insulin Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/GSK1838705A.html
Purity
99.14
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC1=C(C(NC)=O)C(NC2=C3C(NC=C3)=NC(NC4=CC5=C(CCN5C(CN(C)C)=O)C=C4OC)=N2)=CC=C1
Molecular Weight
532.57
References & Citations
[1]Sabbatini P, et al. 
GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers.
Mol Cancer Ther. 2009 Oct;8(10):2811-20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13020/GSK1838705A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13020/GSK1838705A-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1116235-97-2
Available Sizes
Curated Selection
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