Hydroxymethyl dasatinib
Hydroxymethyl dasatinib (M24), a benzylhydroxy metabolite of Dasatinib (HY-10181), exhibits an IC50 of 46.7nM in K562 CML cells[1].
Product Specifications
CAS Number
[910297-58-4]
UNSPSC
12352005
Hazard Statement
H315, H318, H351, H361, H372, H401, H410
Target
Apoptosis; Bcr-Abl; Drug Metabolite; Src
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hydroxymethyl-dasatinib.html
Purity
99.92
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=C(C=CC=C1Cl)CO)C2=CN=C(S2)NC3=CC(N4CCN(CC4)CCO)=NC(C)=N3
Molecular Formula
C22H26ClN7O3S
Molecular Weight
504.00
Precautions
H315, H318, H351, H361, H372, H401, H410
References & Citations
[1]Lisa J Christopher, et al. Metabolism and disposition of dasatinib after oral administration to humans. Drug Metab Dispos. 2008 Jul;36 (7) :1357-64.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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