1-(1-Naphthyl)piperazine (hydrochloride)
Product Specifications
UNSPSC Description
1-1-Naphthylpiperazine hydrochloride (1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride) is a serotonergic derivative of quipazine, which is both an agonist for 5-HT1A receptor and an antagonist for 5-HT2A receptor. 1-1-Naphthylpiperazine hydrochloride induces cell apoptosis. 1-1-Naphthylpiperazine hydrochloride prevents the immunosuppression and photocarcinogenesis[1].
Target Antigen
5-HT Receptor; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis;GPCR/G Protein;Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/1-1-naphthyl-piperazine-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
C12=C(C=CC=C2N3CCNCC3)C=CC=C1.Cl
Molecular Weight
248.75
References & Citations
[1]Menezes AC, et al., Cytotoxic effect of the serotonergic drug 1-(1-Naphthyl)piperazine against melanoma cells. Toxicol In Vitro. 2018 Mar;47:72-78.|[2]Sreevidya CS, et al., Agents that reverse UV-Induced immune suppression and photocarcinogenesis affect DNA repair. J Invest Dermatol. 2010 May;130(5):1428-37.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112538/1-1-Naphthyl-piperazine-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112538/
Clinical Information
No Development Reported
CAS Number
104113-71-5
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