Recombinant Human IL36B
IL36B, also known as Interleukin 36 beta and IL1F8, is a cytokine belonging to the IL-1 family. It is actively secreted and is found to form a cytokine gene cluster on chromosome 2 with eight other IL1 cytokines. IL36B signals through the IL1Rrp2/IL-36R receptor on dendritic cells which then activates NFkB and MAPK signalling pathways to create a pro-inflammatory response. It stimulates the production of mature adipocytes, and IL6 and IL8 synovial fibroblasts. It also induces expression of some antimicrobial peptides and matrix metalloproteases. It is highly expressed in psoriatic plaques, as part of the IL36 signalling system is found in many epithelial barriers.
Product Specifications
Gene Name
IL36B
Gene Aliases
FIL1 eta, Interleukin-1 eta, Interleukin-1 family member 8, Interleukin-1 homolog 2
Gene ID
27177
Accession Number
Q9NZH7
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method
Purity
>95% as determined by SDS-PAGE
Solubility
Reconstitute in sterile PBS at 100µg/mL (containing at least 0.1% human or bovine serum albumin)
Function
IL-36 beta can bind to human IL-1 Rrp2 Fc Chimera with a linear range of 0.15-5 µg/mL as determined by its binding ability in a functional ELISA
Molecular Weight
17.5
Shipping Conditions
Ambient Temperature
Storage Conditions
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 µm filtered solution in PBS (with BSA as a carrier protein)
CAS Number
9000-83-3
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Recombinant Porphyromonas gingivalis Membrane protein insertase YidC (yidC)
