Dot1L-IN-4

Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM[1].

Histone Methyltransferase

Reference compound

Epigenetics

Cancer

https://www.medchemexpress.com/dot1l-in-4.html

O=S(C1=CC=C(N[C@H](C2=NC=CC=C2Cl)C3=C4OC(F)(F)OC4=CC=C3)C(NC5=NC(OC)=NC(N6CCNCC6)=N5)=C1)(C)=O

661.08

[1]Frédéric Stauffer, et al. New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse. ACS Med. Chem. Lett. 2019, 10, 12, 1655-1660.

Room Temperature

http://file.medchemexpress.com/batch_PDF/HY-135127/Dot1L-IN-4-DataSheet-MedChemExpress.pdf

http://file.medchemexpress.com/batch_PDF/HY-135127/Dot1L-IN-4-SDS-MedChemExpress.pdf

2565705-02-2