GB1908
GB1908 is a selective and orally active galectin-1 inhibitor with Ki values of 57 nM and 72 nM for human and mouse galectin-1, respectively. GB1908 displays >50-fold selectivity over galectin-3. GB1908 can be used for the study of lung cancer[1].
Product Specifications
UNSPSC
12352005
Target
Galectin
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gb1908.html
Purity
98.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC(S[C@H]2O[C@H](CO)[C@H](O)[C@H](N3C=C(C4=CSC(O)=N4)N=N3)[C@H]2OC)=CC=C1Cl
Molecular Formula
C18H18Cl2N4O5S2
Molecular Weight
505.40
References & Citations
[1]Fredrik R Zetterberg, et al. Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer. J Med Chem. 2024 May 28.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Galectin-1; Galectin-3
Available Sizes
Curated Selection
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