NTRC-844
NTRC-844 (compound 8) is a selective antagonist of neurotensin receptor type 2 (NTS2), with the EC50 of 238 nM. NTRC-844 plays an important role in analgesic animal research[1].
Product Specifications
CAS Number
[1811503-67-9]
UNSPSC
12352005
Target
Neurotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ntrc-844.html
Purity
95.60
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NN(C(C=C2)=CC=C2F)C(C(C=CC=C3)=C3OC)=C1)NC4([C@H]5C[C@H](C6)C[C@@H]4C[C@H]6C5)C(O)=O
Molecular Formula
C28H28FN3O4
Molecular Weight
489.54
References & Citations
[1]James B Thomas, et al. Identification of 2- ({[1- (4-Fluorophenyl) -5- (2-methoxyphenyl) -1H-pyrazol-3-yl]carbonyl}amino) tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2. ACS Chem Neurosci. 2016 Sep 21;7 (9) :1225-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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