Nrf2 activator-2
Nrf2 activator-2 (compound O15), a Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM in 293 T cells. Nrf2 activator-2 effectively inhibits the interaction between Keap1 and Nrf2, thus showing the activation effect on Nrf2. Nrf2 activator-2 shows a marked decrease in the level of ubiquitinated Nrf2 in cells[1].
Product Specifications
CAS Number
[2770448-53-6]
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nrf2-activator-2.html
Concentration
10mM
Purity
99.20
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1(CCC2=C3OC(C(C4=CC=CC=C4)=CC3=CC(Br)=C2O1)=O)C
Molecular Formula
C20H17BrO3
Molecular Weight
385.25
References & Citations
[1]Weiwei Huang, et al. Design and synthesis of Osthole-based compounds as potential Nrf2 agonists. Bioorg Med Chem Lett. 2022 Apr 1;61:128547.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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