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Anti-p55;50 EBV-Early Antigen(1108-1)

Epstein-Barr virus (EBV), also designated human herpesvirus 4 (HHV-4), is a member of the herpesvirus family and is one of the most common human viruses. EBV infects B cells and, though often asymptomatic, it can cause infectious mononucleosis, a disease characterized by fatigue, fever, sore throat and muscle soreness. The EBV-induced early antigens (Ea) are among several antigen complexes that have been identified in EBV-infected cells. The Ea complex is composed of diffuse (Ea-D) and restricted (Ea-R) components. The activity of Ea-D is suppressed during latent infection. BMRF1, the gene that encodes for Ea-D, is closely associated with the gene encoding for EBV DNA polymerase, and Ea-D is essential for the activity of this polymerase. Ea-D forms a complex with EBV DNase and, together, they may play a role in viral replication._x000D__x000D_Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Specifications

Synonyms

EBNA1; EBV nuclear antigen 1; Epstein Barr nuclear antigen 1; Human Herpesvirus 4 (HHV4)

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

UniProt

Not Applicable

Cellular Locus

Nucleus

Host

Mouse

Species Reactivity

EBV

Target Antigen

p55;50 EBV Early Antigen

Clonality

Monoclonal

Isotype

IgG1 κ

Clone

1108-1

Conjugation

Purified, with BSA

Source

Animal

Applications

IF (published) | IP (published) | WB (published)

Validated Applications

IF,IP,WB

Field of Research

Infectious disease, Virology

Positive Control

EBV-infected cells or tissues

Concentration

0.2 mg/mL

Buffer

PBS, 0.05% BSA, 0.05% azide

Molecular Weight

50/55 kDa doublet

Additionnal Information

Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunofluorescence: 0.5-1 ug/mL|Optimal dilution for a specific application should be determined by user

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. J Virol (1984) 50(2): 372-379. (IP, WB, IF) PLoS ONE 7(11): e48788. (IHC, FFPE)

Shipping Conditions

Room temperature

Storage Conditions

4°C; Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

2 years

Product Datasheet

https://cdn.gentaur.com/products/37/889506/datasheet/bnub0103-100.pdf

Product MSDS

https://cdn.gentaur.com/products/37/889506/msds/bnub0103-100.pdf

CAS Number

9007-83-4

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