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Avanafil-13C,d3

Product Specifications

UNSPSC Description

Avanafil-13C,d3 is the 13C- and deuterium labeled Avanafil.

Target Antigen

Isotope-Labeled Compounds; Phosphodiesterase (PDE)

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease;Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Solubility

10 mM in DMSO

Smiles

ClC1=C(O[13C]([2H])([2H])[2H])C=CC(CNC2=C(C(NCC3=NC=CC=N3)=O)C=NC(N4[C@H](CO)CCC4)=N2)=C1

Molecular Weight

487.96

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.|[2]Kotera J, et al. Avanafil, a potent and highly selective phosphodiesterase-5 inhibitor for erectile dysfunction. J Urol. 2012 Aug;188(2):668-74.|[3]Mochida H, et al. Avanafil, a highly selective phosphodiesterase type 5 inhibitor for erectile dysfunction, shows good safety profiles for retinal function and hemodynamics in anesthetized dogs. J Urol. 2013 Aug;190(2):799-806.|[4]Wang R, et al. Selectivity of avanafil, a PDE5 inhibitor for the treatment of erectile dysfunction: implications for clinical safety and improved tolerability. J Sex Med. 2012 Aug;9(8):2122-9.

Shipping Conditions

Room temperature

Clinical Information

No Development Reported

CAS Number

2738376-89-9

Available Sizes

Curated Selection

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